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Introduction. Physical fatigue is a physiological condition that can be measured by functional Magnetic Resonance Imaging (fMRI).

Aim. Therefore, this work aims to present the research results currently reported in the scientific literature between the years 2014 and 2018 in the field of chronic fatigue syndrome using the functional MRI method.

Material and methods. Analysis of literature.

Results. We reviewed here the differences between temporary and chronic fatigue.