Infliximab MRI relaxation time in solution

Zuzanna Bober
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Piotr Bar
Grzegorz Pasternak
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Sabina Galiniak
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Dorota Bartusik-Aebisher
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Rafal Filip
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David Aebisher
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Department of Photomedicine and Physical Chemistry, Medical College of University of Rzeszów, Rzeszów, Poland
Clinical Department of Pathomorphology, Clinical Hospital No. 2, Rzeszów, Poland
Department of Gastroenterology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland
Department of Biochemistry and General Chemistry Medical College of Rzeszów University, Rzeszów, Poland
Department of Biochemistry and General Chemistry, Medical College of the University of Rzeszow, University of Rzeszow, Rzeszow, Poland
Department of Gastroenterology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland
Department of Photomedicine and Physical Chemistry, Medical College of Rzeszów University, Rzeszów, Poland
Received: 1 September 2018 / Accepted: 13 November 2018 / Published: 30 March 2019

Abstract

Introduction. The use of Quantitative Magnetic Resonance Imaging to drug monitoring in vitro or in vivo can provides a powerful means to map the effects of drugs on tissue activity.

Aim. The purpose of this study was to measure relaxation time of antibody phantom. For this purpose, infliximab sample was used.

Material and methods. The selected methods to detect relaxation time of antibody was Magnetic Resonance Imaging technique. We detected spin-lattice (T1) relaxation time and discuss differences where compare to water.

Results. The measurements of spin-lattice (T1) relaxation time showed significant differences. The results obtained in phantom indicate that we can use this result for measurements of relaxation time in vitro.

Conclusion. Infliximab is approved for severe cases of rheumatoid arthritis, together with methotrexate, for pronounced psoriasis and psoriasis-arthritis, ankylosing spondylitis as well as for chronic inflammatory bowel disease. We conclude, that Quantitative Magnetic Resonance Imaging can be used to monitor drug effects. 

 

Cite

Bober Z, Bar P, Pasternak G, Galiniak S, Bartusik-Aebisher D, Filip R, Aebisher D. Infliximab MRI relaxation time in solution. Eur J Clin Exp Med. 2019;17(1):22–25. doi: 10.15584/ejcem.2019.1.4

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