Introduction. Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the serum levels of vitamin D and alterations in inflammation in different vitamin D status is presently lacking.
Aim. To determine the serum levels of vitamin D and TNF-α, and assess their possible relationship with gender in individuals with MS.
Material and methods. Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-α levels were measured and participants stratified into different vitamin D status.
Results. None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-α level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-α level in MS. Also vitamin D level was significantly lower while TNF-α level was significantly higher in female-MS compared with the male-MS.
Conclusion. Adults with MS have elevated TNF-α level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.
Cite
Rahamon SK, Arinola OG, Charles-Davies MA, et al. Serum levels of vitamin D and tumour necrosis factor-alpha in adults with metabolic syndrome. Eur J Clin Exp Med. 2021;19(4):306–312. doi: 10.15584/ejcem.2021.4.3.
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