Szymon Skoczen
Miroslaw Bik-Multanowski
Walentyna Balwierz
Jacek J. Pietrzyk
The rs9939609T>A polymorphism of the FTO gene and overweight in survivors of ALL
Szymon Skoczen
Miroslaw Bik-Multanowski
Walentyna Balwierz
Jacek J. Pietrzyk
Chair of Clinical Immunology and Transplantation, Jagiellonian University Krakow, Poland
Chair of Pediatrics, Jagiellonian University Krakow, Poland
Department of Oncology and Hematology, Jagiellonian University Krakow, Poland
Chair of Pediatrics, Jagiellonian University Krakow, Poland
Abstract
Background: Overweight is a serious late complication of acute lymphoblastic leukemia (ALL). The aim of the study was to assess the role of the rs9939609T>A polymorphism of the FTO gene in development of overweight in ALL survivors.
Methods: Genotyping for the above genetic variant was performed in 191 patients, who completed treatment for ALL.
Results: The presence of the rs9939609A allele correlated with post-treatment overweight incidence in patients receiving cranial radiotherapy, whereas the rs9939609T allele seemed to protect against overweight development.
Conclusion: The rs9939609T>A variant can influence overweight risk in selected patients with ALL.
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