The rs9939609T>A polymorphism of the FTO gene and overweight in survivors of ALL
Abstract
Background: Overweight is a serious late complication of acute lymphoblastic leukemia (ALL). The aim of the study was to assess the role of the rs9939609T>A polymorphism of the FTO gene in development of overweight in ALL survivors.
Methods: Genotyping for the above genetic variant was performed in 191 patients, who completed treatment for ALL.
Results: The presence of the rs9939609A allele correlated with post-treatment overweight incidence in patients receiving cranial radiotherapy, whereas the rs9939609T allele seemed to protect against overweight development.
Conclusion: The rs9939609T>A variant can influence overweight risk in selected patients with ALL.
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