Artur Słomka
Wiesława Włodarczak
Ewa Żekanowska
The role of non-transferrin bound iron in pathophysiology of human diseases
Artur Słomka
Wiesława Włodarczak
Ewa Żekanowska
Zakład Zaburzeń Hemostazy Katedry Patofizjologii Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Polska
Instytut Ochrony Zdrowia, Państwowa Wyższa Szkoła Zawodowa im. Stanisława Staszica w Pile
Katedra Patofizjologii, Collegium Medicum UMK w Bydgoszczy, Polska
Abstract
Iron is an essential element for oxygen transport, nucleic acids synthesis, cell growth and proliferation. The free iron called non-transferrin bound iron (NTBI) is toxic, it generates reactive oxygen species, causing damage of all biomolecules. Non-transferrin bound iron may play the central role in pathogenesis and progresion of haematological diseases and also in pathophysiology of central nervous system damages in newborns, neurodegenerative disorders and diabetes.
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