Premature thelarche – pathogenesis and management

Aleksandra Januszek-Trzciąkowska
Ewa Małecka-Tendera
Maria Kalina
Barbara Kalina-Faska
Z Katedry i Kliniki Pediatrii, Endokrynologii i Diabetologii Dziecięcej Śląskiej Akademii Medycznej w Katowicach
Z Katedry i Kliniki Pediatrii, Endokrynologii i Diabetologii Dziecięcej Śląskiej Akademii Medycznej w Katowicach
Z Katedry i Kliniki Pediatrii, Endokrynologii i Diabetologii Dziecięcej Śląskiej Akademii Medycznej w Katowicach
Z Katedry i Kliniki Pediatrii, Endokrynologii i Diabetologii Dziecięcej Śląskiej Akademii Medycznej w Katowicach

Abstract

Precocious breast development in girls (thelarche praecox) is an isolated variant of precocious puberty, regressing spontaneously in vast majority of patients. Pathogenesis of this phenomenon has not been identified. Most authors explain it by incomplete activation of the hypothalamic-pituitary-gonadal axis or by hypersensitivity of the glandular tissue to low, physiological fluctuations of estrogens concentrations. From the clinical point of view the most essential is to differentiate this form from true central precocious puberty, as well as to carefully follow up intermediate variants which may exhibit slow progression.

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