Igor L. Popovych
Walery Zukow
Oksana I. Melnyk
Vitalii M. Fil
Halyna Y. Kovalchuk
Iryna V. Bryndzia
Olena R. Voloshyn
Iryna Y. Kopko
Oksana M. Lupak
Taras B. Skrobach
Mariana М. Kravtsiv
Olena V. Musiyenko
Dariya V. Popovych
Neuroendocrine and metabolic predictors of the effects of balneotherapy at the Truskavets Spa on physical working capacity in men with maladaptation
Igor L. Popovych
Walery Zukow
Oksana I. Melnyk
Vitalii M. Fil
Halyna Y. Kovalchuk
Iryna V. Bryndzia
Olena R. Voloshyn
Iryna Y. Kopko
Oksana M. Lupak
Taras B. Skrobach
Mariana М. Kravtsiv
Olena V. Musiyenko
Dariya V. Popovych
Bohomolets’ Institute of Physiology of NAS, Kyiv, Ukraine
Nicolaus Copernicus University, Torun, Poland
Danylo Halytskyıˇ National Medical University, Lviv, Ukraine
Ivan Franko State Pedagogical University, Drohobych, Ukraine
Ivan Franko State Pedagogical University, Drohobych, Ukraine
Ivan Franko State Pedagogical University, Drohobych, Ukraine
Ivan Franko State Pedagogical University, Drohobych, Ukraine
Ivan Franko State Pedagogical University, Drohobych, Ukraine
Ivan Franko State Pedagogical University, Drohobych, Ukraine
Ivan Franko State Pedagogical University, Drohobych, Ukraine
Ivan Franko State Pedagogical University, Drohobych, Ukraine
Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Lviv, Ukraine
IY Horbachevskyi National Medical University, Ternopil, Ukraine
Received: 10 June 2024 / Revised: 1 August 2024 / Accepted: 16 August 2024 / Published: 30 March 2025
Abstract
Introduction and aim. The effect of balneotherapy in the Truskavets Spa on physical working capacity is complex and individ ualized. This study aims to identify an optimal constellation of predictors for the actotropic effects of balneotherapy.
Material and methods. We observed 34 men with maladaptation against the background of chronic pyelonephritis in remis sion. We recorded physical working capacity, heart rate variability, electroencephalography, adaptation hormones, and blood and urine metabolites before and after a standardized balneotherapy regimen.
Results. Standard balneotherapy resulted in various effects on physical working capacity150 : an increase in 9 patients (26.5%), no significant change in 16 patients (47.1%), and a decrease in 9 patients (26.5%). Through discriminant analysis, we identified a constellation of 25 initial parameters that could predict the nature of the actotropic effect with 100% accuracy. These parameters included measures of physical working capacity, cardiorespiratory fitness, electroencephalography, heart rate variability, hormones, and metabolism. Furthermore, multiple linear regression analysis allowed us to predict quantitative changes in physical work capacity150 with a standard error of 0.28 W/kg. This predictive model incorporated hemodynamic and Electroen cephalography parameters, achieving an adjusted R2 of 0.555.
Conclusion. The directionality and magnitude of physical working capacity150 changes under the influence of balneofactors at the Truskavets Spa are determined by a complex constellation of initial physiological parameters, which forms the body’s reactivity. This finding has significant implications for personalizing balneotherapy treatments.
Cite
Popovych IL, Zukow W, Melnyk OI, et al. Neuroendocrine and metabolic predictors of the effects of balneotherapy at the Truskavets Spa on physical working capacity in men with maladaptation. Eur J Clin Exp Med. 2025;23(1):38–52. doi: 10.15584/ejcem.2025.1.4.
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