Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy

Zuzanna Bober
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David Aebisher
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Jacek Tabarkiewicz
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Wiesław Guz
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Piotr Tutka
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Dorota Bartusik-Aebisher
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Department of Photomedicine and Physical Chemistry, Medical College of University of Rzeszów, Rzeszów, Poland
Department of Photomedicine and Physical Chemistry, Medical College of Rzeszów University, Rzeszów, Poland
Department of Human Immunology, Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland
Clinical Department of Radiology and Diagnostic Imaging, Clinical Provincial Hospital No. 2 Saint Jadwiga Queen in Rzeszów, Poland
Department of Pharmacology, Medical College of University of Rzeszow, Rzeszów, Poland
Department of Biochemistry and General Chemistry, Medical College of the University of Rzeszow, University of Rzeszow, Rzeszow, Poland
Received: 16 January 2017 / Accepted: 18 April 2017 / Published: 30 June 2017

Abstract

Currently, new and easier ways of analyzing pharmaceutical drug forms and drug delivery mechanisms are being sought. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that images drug forms such as tablets, liquids and topicals and drug form behavior in living organisms on both the tissue and cellular scale. The advantages of MRI include noninvasiveness, variable sample capacity and ease of transfer of phantom results to in vitro and in vivo studies. This review concerns the usefulness of clinical MRI that cannot be understated as this technique provides non-invasive and non-destructive insight into the properties of drug delivery systems. The research discussed here concerns the use of magnetic resonance, spectroscopy and chromatography to investigate selected pharmaceuticals and covers work of selecting drugs and antibodies for modification by synthesis for evaluation by MRI. Modifications have been aimed at improving therapeutic efficacy, delivery, and MRI. Modification conditions such as (pH, concentration, temperature, and the influence of other components present in the solutions) will be discussed to understand drug delivery system improvements and the reliability and repeatability of the results obtained. We hope to explore and expand the scope of pharmaceutical imaging with MRI for application in clinical medicine.

 

Cite

Bober Z, Aebisher D, Tabarkiewicz J, Guz W, Tutka P, Bartusik-Aebisher D. Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy. Eur J Clin Exp Med. 2017;15(2):110–119. doi: 10.15584/ejcem.2017.2.3

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