Inflammatory bowel disease: the function of metalloproteinases

Grzegorz Pasternak
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David Aebisher
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Rafal Filip
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Dorota Bartusik-Aebisher
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Department of Gastroenterology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland
Department of Photomedicine and Physical Chemistry, Medical College of Rzeszów University, Rzeszów, Poland
Department of Gastroenterology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland
Department of Biochemistry and General Chemistry, Medical College of the University of Rzeszow, University of Rzeszow, Rzeszow, Poland
Received: 5 September 2018 / Accepted: 20 October 2018 / Published: 30 December 2018

Abstract

Introduction. Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine.

Aim. The aim of this work was to review the current literature regarding matrix metalloproteinases. The databases such as PubMed, ScienceDirect and Springer were utilized to search the literature for relevant articles.

Material and methods. An analysis of literature. We collected information, data, and examples of the function of metalloproteinases.

Results. Herein we show that metalloproteinases play a role in such processes as the immune response, angiogenesis, the epithelial barrier function, fibrosis induced by the inflammatory process, and in the process of carcinogenesis.

Conclusion. Further studies on the role of metalloproteinases in the process of carcinogenesis associated with inflammatory bowel diseases are required. 

 

Cite

Pasternak G, Aebisher D, Filip R, Bartusik-Aebisher D. Inflammatory bowel disease: the function of metalloproteinases. Eur J Clin Exp Med. 2018;16(4):346–349. doi: 10.15584/ejcem.2018.4.13

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