Incidental vs. non-incidental gallbladder cancer – a hospital-based clinicopathological study

Sashibhusan Dash
ID
Prajna Anirvan
ID
Sagarika Samantaray
ID
Niranjan Rout
ID
Manoranjan Ranjit
ID
Department of Molecular Epidemiology, ICMR-Regional Medical Research Centre, Bhubaneswar, India
Department of Translational Research, Kalinga Gastroenterology Foundation, Cuttack, India
Department of Pathology, Acharya Harihar Post-Graduate Institute of Cancer, Cuttack, India
Acharya Harihar Post-Graduate Institute of Cancer, Cuttack, India
Department of Molecular Epidemiology, ICMR-Regional Medical Research Centre, Bhubaneswar, India
Received: 3 December 2023 / Revised: 14 April 2024 / Accepted: 16 April 2024 / Published: 30 September 2024

Abstract

Introduction and aim. Most gallbladder cancers (GBCs) are discovered incidentally after routine cholecystectomy. The clinicopathological characteristics and prognostic implications of incidental gallbladder cancer (IGBC) versus non-incidental gallbladder cancer (NIGBC) is not known.

Material and methods. During this study, clinicopathological details compared between incidental and non-incidental GBC groups included age, sex, clinical presentation, preoperative radiological diagnosis, surgical management, and macroscopic and microscopic features. The primary outcome of the study was difference in overall survival (OS) between IGBC and NIGBC.

Results. Among 348 surgically treated patients, 56.6% weren’t preoperatively suspected of GBC. Macroscopic examination showed characteristic thickened gallbladder wall without mass lesion (IGBC) vs. clear mass lesion (NIGBC) on imaging. Interestingly, NIGBC had higher LVI (27% vs. 14%) and T stage (68% T2b/T3 vs. 47% T1b/T2a) despite lower margin involvement (p < 0.001). The OS for all patients was 12.2 months (median). Among patients who underwent surgery with curative intent, the median survival time was 21.4 months. However, within this group, NIGBC cases had a worse median survival (17 months) compared to IGBC cases (21 months).

Conclusion. Rising incidental GBC necessitates routine microscopic examination of all gallbladder specimens. Surgeons in high-risk areas should remain vigilant for GBC in patients with atypical clinical and ultrasound findings. Early detection and curative resection are paramount for long-term survival in gallbladder carcinoma, with IGBC potentially offering a survival benefit regardless of stage or tumor characteristics. Prospective studies including detailed pathology and molecular analysis are needed to confirm this observation.

 

Cite 

Dash S, Anirvan P, Samantaray S, Rout N, Ranjit M. Incidental vs. non-incidental gallbladder cancer – a hospital-based clinicopathological study. Eur J Clin Exp Med. 2024;22(3):575–581. doi: 10.15584/ejcem.2024.3.17.

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