Growth differentiation factor 15 – a review of current literature on biological roles and clinical significance

Bartosz Rzemieniewski
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Aleksandra Kasztelan
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Kamil Poboży
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Julia Domańska-Poboża
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Faculty of Medicine, Cardinal Stefan Wyszyński University, Warsaw, Poland
Faculty of Medicine, Cardinal Stefan Wyszyński University, Warsaw, Poland
Department of Neurosurgery, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland
Department of Rheumatology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland
Received: 14 April 2024 / Revised: 29 June 2024 / Accepted: 4 July 2024 / Published: 30 December 2024

Abstract

Introduction and aim. Growth differentiation factor 15 (GDF15), a member of the TGF-β superfamily, plays crucial roles in various physiological and pathological processes including inflammation, apoptosis, angiogenesis, cell repair, growth, metabolic regulation, and immune response. This review aims to discuss the biological roles and clinical significance of GDF15 and to analyze its impact across different medical fields such as cardiology, oncology, neurology, gynecology, and areas related to aging and metabolic disorders.

Material and methods. A review was constructed through a literature search on PubMed and Google Scholar databases, focusing on studies from 2014 to 2024, using relevant keywords.

Analysis of the literature. Recent research highlights GDF15’s potential as a biomarker in cardiovascular diseases, its role in cancer progression and resistance to therapies, and its significance in metabolic regulation affecting conditions like obesity, diabetes, and cachexia. Emerging research also points to its role in aging, mitochondrial diseases, and systemic conditions such as sepsis, liver, and lung disorders.

Conclusion. GDF15’s involvement in multiple pathological states and its broad impact across various medical disciplines underline its potential for future clinical applications. Understanding GDF15’s complex roles could lead to novel therapeutic strategies and enhance prognostic assessments in diverse medical fields.

 

Cite

Rzemieniewski B, Kasztelan A, Poboży K, Domańska-Poboża J. Growth differentiation factor 15 – a review of current literature on biological roles and clinical significance. Eur J Clin Exp Med. 2024;22(4):921–933. doi: 10.15584/ejcem.2024.4.19.

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