Effects of vitamin D3 supplementation on lipid profile and renal indices in rat model of drug induced renal injury

Ayobola A. Sonuga
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Motunrayo M. Adeyanju
Olusola A. Ladokun
Oyebola O. Sonuga
Department of Biochemistry, Faculty of Natural and Applied Sciences, Lead City University. Ibadan, Nigeria
Department of Biochemistry, Faculty of Natural and Applied Sciences, Lead City University. Ibadan, Nigeria
Department of Biochemistry, Faculty of Natural and Applied Sciences, Lead City University. Ibadan, Nigeria
Chemical Pathology Department, Faculty of Basic Medical Sciences, University College Hospital, Ibadan, Nigeria
Received: 5 April 2024 / Revised: 24 May 2024 / Accepted: 31 May 2024 / Published: 30 December 2024

Abstract

Introduction and aim. Renal injury is associated with decreased renal function, hypovitaminosis D, deranged calcium-phos phate metabolism and dyslipidemia, thus increasing risk for chronic kidney disease and cardiovascular diseases. However, re ports on the effects of vitamin D on drug induced renal injury are few. The aim was to investigate the possible role of vitamin D supplementation in reversing deranged lipid profile and renal function post drug induced renal injury.

Material and methods. Wister male rats (36) were randomly divided into group 1, 2 and 3 (n=12). Single dose of Adriamycin was given to all except group 1(control) to induce renal injury. Group 2 left untreated, group 3 given vitamin D3 for 28 days. Serum urea, creatinine, total protein, total cholesterol (TC), triglycerides (TG), LDL-C, HDL, apolipoprotein (Apo) A and B were measured. C-reactive protein (CRP) and nitric oxide were assessed in kidney homogenate.

Results. Vitamin D3 significantly brought down levels of serum creatinine, TC, LDL CRP, nitric oxide and increased the levels of Apo A, albumin, HDL. Serum urea, TG and Apo B in group 3 were not significantly different after vitamin D3 administration. His tological examination revealed improvement in glomerular messangialisation.

Conclusion. Vitamin D3 may improve renal health, through its positive impact on dyslipidemia, inflammation, and oxidative stress in drug induced renal injury.

 

Cite

Sonuga AA, Adeyanju MM, Ladokun OA, Sonuga OO. Effects of vitamin D3 supplementation on lipid profile and renal indices in rat model of drug induced renal injury. Eur J Clin Exp Med. 2024;22(4):729–738. doi: 10.15584/ejcem.2024.4.7.

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