Cytisine parameters measured in the 1.5 Tesla magnetic field

Zuzanna Bober
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Sabina Galiniak
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Dawid Leksa
Klaudia Dynarowicz
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David Aebisher
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Elżbieta Ostańska
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Anna Czmil
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Piotr Bar
Dorota Bartusik-Aebisher
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Piotr Tutka
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Department of Photomedicine and Physical Chemistry, Medical College of University of Rzeszów, Rzeszów, Poland
Department of Biochemistry and General Chemistry Medical College of Rzeszów University, Rzeszów, Poland
Rzeszów Center for Vascular and Endovascular Surgery, Rzeszow, Poland
Department of Photomedicine and Physical Chemistry, Medical College of The University of Rzeszów, University of Rzeszów, Poland
Department of Photomedicine and Physical Chemistry, Medical College of Rzeszów University, Rzeszów, Poland
Clinical Department of Pathomorphology, Clinical Hospital No. 1 in Rzeszow, Rzeszow, Poland
Department of Computer Sciences, Rzeszów University of Technology, Rzeszów, Poland
Clinical Department of Pathomorphology, Clinical Hospital No. 2, Rzeszów, Poland
Department of Biochemistry and General Chemistry, Medical College of the University of Rzeszow, University of Rzeszow, Rzeszow, Poland
Department of Pharmacology, Medical College of University of Rzeszow, Rzeszów, Poland
Received: 7 September 2019 / Accepted: 19 December 2019 / Published: 30 March 2020

Abstract

Introduction. Cytisine, Cytisinum (C11H14N2O), is an organic chemical compound. Cytisine is heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family.

Aim. The aim of the study is to measure the influence of water on the form of drug in the magnetic field 1.5 Tesla.

Material and methods. For this purpose, magnetic resonance imaging tests were performed to check the solubility of pure cytisine, Desmoxan tablets and Tabex capsules.

Results. From a pharmacological point of view, both Desmoxan tablets and Tabex capsules should exert the same effect on the human body, this is due to the identical content of the active substance, in this case cytisine (1.5 mg).

Conclusion. The differences in the results obtained may be related to additional excipients that contain medications, but it is believed that they should not have a negative impact on the action of the active substance. 

 

Cite

Bober Z, Galiniak S, Leksa D, et al. Cytisine parameters measured in the 1.5 Tesla magnetic field. Eur J Clin Exp Med. 2020;18(1):16– 19. doi: 10.15584/ejcem.2020.1.3

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