Connection between concentration of soluble forms of adhesion molecules and the volume of ischemic region in brain stroke

Edyta Matusik
Andrzej Wajgt
Joanna Janowska
Barbara Zahorska-Markiewicz
Z Katedry i Kliniki Neurologii, Śląskiej Akademii Medycznej, Katowice-Ligota
Z Katedry i Kliniki Neurologii, Śląskiej Akademii Medycznej, Katowice-Ligota
Katedra i Zakład Patofizjologii, Śląska Akademia Medyczna, Katowice
Katedra i Zakład Patofizjologii, Śląska Akademia Medyczna, Katowice

Abstract

It exists strong interaction between nervous and immune system during cerebral ischemia. The consequence are the complex interactions which lead to the immune cells migration through the blood-brain barrier. In this barrier crossing adhesion molecules play the crucial role, which soluble forms are releasing into the circulation. The aim of the study was to establish that soluble forms of adhesion molecules correlate with the volume of ischemic region. The study was conducted in 36 patients with ischemic stroke. In the study group (SG) of stroke patients sICAM-1 (soluble intracellular adhesion molecule-1) and sVCAM-1 (soluble vascular cell adhesion molecule-1) levels in the 1st, 5th and 14th day of ischemic stroke were assessed (ELISA). The volume of ischemic focus based on CT scans was assessed in every patient. Significant correlation (r = 0,332; p< 0,05) between initial sICAM-1 level and stroke volume was observed. There were no significant correlation with sICAM-1 levels in the further phase of stroke. sVCAM-1 levels did not correlate significantly with stroke volume. The following conclusion was drawn: The initial level of sICAM-1 may be the indication of the focus volume in ischemic stroke.

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