A comparative study of pharmacological, nonpharmacological, and combined methods of induction of labor

Puri Sudha Unmesh
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Bharati Vinod Murlidhar
Latpate Raosaheb Vikram
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Department of Pharmacology, JSPM’s Jayawantrao Sawant College of Pharmacy & Research, Hadapsar, Pune, Maharashtra, India
Rising Medicare Hospital, Mundhwa – Kharadi Rd, Behind Radisson Blu, Pandhari Nagar, Kharadi, Pune, Maharashtra, India
Department of Statistics, Savitribai Phule Pune University, Ganeshkhind Rd, Ganeshkhind, Pune, Maharashtra, India
Received: 25 September 2024 / Revised: 28 October 2024 / Accepted: 29 October 2024 / Published: 30 March 2025

Abstract

Introduction and aim. Induction of labor (IOL), a common obstetric procedure, aims to induce labor. The study defined labor induction success as true uterine contractions and classified delivery outcomes as vaginal, instrumental, and cesarean. A higher Bishop score predicts a vaginal delivery. The objective was to compare cervical status, induction success, cesarean section rates, and normal delivery rates of pharmacological and non-pharmacological IOL methods.

Material and methods. In this study, 296 pregnant women admitted to the labor room were divided into three groups: those who received pharmacological agents (25 μg/50 μg misoprostol or dinoprostone 5 g gel to start labor), those who were giv en non-pharmacological agents (Foley’s catheter and membrane stripping to start labor), and those who were given both non-pharmacological and pharmacological agents (Foley’s catheter and membrane stripping followed by oxytocin to start labor).

Results. Although a 92.5% induction success rate, the use of non-pharmacological methods alone led to a rate of 49.06% cesar ean section rate. Combined with a pharmacological agent such as oxytocin, it achieved almost the same success rate (91.43%) as a pharmacological method of inducing labor (18.57%). This resulted in a lower rate of cesarean section than pharmacological and nonpharmacological methods (p=0.002).

Conclusion. Nonpharmacological IOL methods alone led to higher cesarean rates despite improved cervical status. Combining them with pharmacological agents such as oxytocin resulted in higher normal delivery rates and fewer cesarean sections, indicating a more effective approach for improving delivery outcomes.

 

Cite 

Unmesh PS, Murlidhar BV, Vikram LR. A comparative study of pharmacological, nonpharmacological, and combined methods of induction of labor. Eur J Clin Exp Med. 2025;23(1):163–172. doi: 10.15584/ejcem.2025.1.26

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