Al-Noor Opied Al-Tayeb
Mohammed Hayati Abubakr
Hafsa Ahmed Elrheima
Ahmed Khalid Habbani
Rami Y. Hassab Elrasul
Assessment of serum creatinine, urea, and aminotransferase levels among methamphetamine addicted individuals in Khartoum State
Al-Noor Opied Al-Tayeb
Mohammed Hayati Abubakr
Hafsa Ahmed Elrheima
Ahmed Khalid Habbani
Rami Y. Hassab Elrasul
Chemical Pathology Department, Faculty of Medical Laboratory Science, University of Medical Sciences and Technology, Khartoum, Sudan
Chemical Pathology Department, Faculty of Medical Laboratory Science, University of Medical Sciences and Technology, Khartoum, Sudan
Chemical Pathology Department, Faculty of Medical Laboratory Science, University of Medical Sciences and Technology, Khartoum, Sudan
Histopathology and Cytology Department, Faculty of Medical Laboratory Science, University of Medical Sciences and Technology, Khartoum, Sudan
Biostatistics, Faculty of Medical Laboratory Science, Nepta College, Khartoum, Sudan
Received: 6 September 2023 / Revised: 4 November 2023 / Accepted: 6 November 2023 / Published: 30 March 2024
Abstract
Introduction and aim. Methamphetamine-use disorder is a pressing global public health issue. In Sudan, the escalating meth amphetamine (METH) consumption has become a significant social and health problem. This study aims to evaluate liver and kidney biomarkers in methamphetamine addicts in Khartoum state
Material and methods. The study was an analytical prospective cross-sectional hospital-based study. One hundred partici pants were enrolled in this study, fifty were cases (methamphetamine addicts), and others were healthy non-METH users as a comparative group.
Results. METH users had a mean age of (27±7) years and had been using METH for an average of (14±9) months. Urea and cre atinine levels were also significantly elevated in METH users compared to non-users, with p<0.001 and p=0.044, respectively. Their aspartate transaminase (AST) and alanine transaminase (ALT) levels were significantly higher compared to non-users, with p<0.001.
Conclusion. There was significant increases in creatinine, urea, and aminotransferases levels in the case group. ALT showed a moderate positive correlation with abuse duration, while AST showed no significant correlation. Urea and creatinine levels had strong and moderate positive correlations with abuse duration, respectively.
Cite
Al-Tayeb A-NO, Abubakr MH, Elrheima HA, Habbani AK, Elrasul RYH. Assessment of serum creatinine, urea, and aminotransfera se levels among methamphetamine addicted individuals in Khartoum State. Eur J Clin Exp Med. 2024;22(1):68–72. doi: 10.15584/ ejcem.2024.1.10.
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