19 F MRI As a tool for imaging drug delivery to tissue and individual cells

Zuzanna Bober
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David Aebisher
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Łukasz Ożóg
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Jacek Tabarkiewicz
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Piotr Tutka
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Dorota Bartusik-Aebisher
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Department of Photomedicine and Physical Chemistry, Medical College of University of Rzeszów, Rzeszów, Poland
Department of Photomedicine and Physical Chemistry, Medical College of Rzeszów University, Rzeszów, Poland
Department of Photomedicine and Physical Chemistry, Medical College of Rzeszów University, Rzeszów, Poland
Department of Human Immunology, Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland
Department of Pharmacology, Medical College of University of Rzeszow, Rzeszów, Poland
Department of Biochemistry and General Chemistry, Medical College of the University of Rzeszow, University of Rzeszow, Rzeszow, Poland
Received: 22 February 2017 / Accepted: 24 April 2017 / Published: 30 June 2017

Abstract

Over the past few decades, magnetic resonance imaging (MRI) has proven to be extremely successful in medical applications. More recently, the biomedical applications of MRI have been gaining more use in the field of clinical pharmacy. In 1977, perfluorocarbon compounds (PFC), which form emulsions that can carry drugs, were analyzed by 19F MRI and emulsified PFC compounds have been investigated as potential blood substitutes since the early 1960s and now a wide variety of PFC compounds are currently available as 19F MRI biomarkers. Molecules with 19F substituents are particularly attractive for use in drug tracking by 19F MRI due to 100% 19F abundance, high 19F MRI sensitivity (0.83 relative to 1 H MRI) and an impressively large chemical shift range (400 ppm). Another benefit in the use of 19F MRI is a zero background signal in biological samples due to lack of endogenous fluorine. Therefore, drugs containing fluorine atom have potential for 19F MRI imaging drug delivery to tissue. This article will review recent developments in the use of 19F MRI in imaging drug delivery to tissue and individual cells.

 

Cite

Bober Z, Aebisher D, Ożóg Ł, Tabarkiewicz J, TutkaP, Bartusik-Aebisher D. 19F MRI As a tool for imaging drug delivery to tissue and individual cells. Eur J Clin Exp Med. 2017;15(2):99–109. doi: 10.15584/ejcem.2017.2.2

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