Exploring the versatility of ciclopirox – from anti-fungal to anticancer agent and beyond

Dhishank Singh
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Ginpreet Kaur
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Meena Chintamaneni
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Hemant Joshi
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Seema Ramniwas
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Hardeep Singh Tuli
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Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s Narsee Monjee Institute of Management Studies, Vile Parle, Mumbai, India
Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s Narsee Monjee Institute of Management Studies, Vile Parle, Mumbai, India
Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s Narsee Monjee Institute of Management Studies, Vile Parle, Mumbai, India
School of Biotechnology, Jawaharlal Nehru University, New Delhi, India
University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali, India
Department of Bio-Sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Haryana, India
Received: 29 June 2023 / Revised: 31 August 2023 / Accepted: 16 September 2023 / Published: 30 December 2023

Abstract

Introduction and aim. Ciclopirox has been treating fungal infections for decades. Recent studies suggest ciclopirox may be repurposed to treat cancer, viral infections, and neurological disorders. Ciclopirox exerts anticancer by inhibiting multiple pathways of cancer cell growth and survival and anti-viral actions by reducing viral replication and altering the host immunological response to viral infection. Recent research suggests that ciclopirox may protect against neurodegenerative illnesses including Alzheimer’s and Parkinson’s. This narrative review shows ciclopirox’s potential to treat cancer, viral infections, and neurological diseases.

Material and methods. Current relevant research publications focused on ciclopirox and its repurposing medicinal potential, therefore a well-designed technique was used to find them. „Ciclopirox”, „Anti-fungal”, „Anti-cancer”, „Repurposing”, and „Therapeutic potential” were used to search PubMed, Web of Science, EMBASE, and Google Scholar.

Analysis of literature. Ciclopirox may reduce oxidative stress and inflammation, which may cause several illnesses. Overall, the repurposing of ciclopirox for the treatment of cancer, viral infections, and neurodegenerative disorders represents a promising avenue of research that warrants further investigation.

Conclusion. It was concluded that CPX and olamine derivatives as outstanding antifungal medications, as well as provide information on ongoing research to use them for other illnesses.

 

Cite

Singh D, Kaur G, Chintamaneni M, Joshi H, Ramniwas S, Tuli HS. Exploring the versatility of ciclopirox – from anti-fungal to anticancer agent and beyond. Eur J Clin Exp Med. 2023;21(4):896–908. doi: 10.15584/ejcem.2023.4.26.

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