Oxidative and nitrosative stress in patients with meningitis

Emine Siber Namiduru
ID
Email src
Mustafa Namiduru
ID
İlkay Karaoğlan
ID
Kübra Koçak
ID
Department of Nutrition and Dietetics, Faculty of Health Sciences, University of Gaziantep, Gaziantep, Turkey
Department of Infectious Disease, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
Department of Infectious Disease, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
Department of Infectious Disease, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
Received: 18 November 2021 / Revised: 27 December 2021 / Accepted: 27 December 2021 / Published: 30 March 2022

Abstract

Introduction and aim. Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known as the meninges. In this study, oxidative and nitrosative stress were evaluated in cerebrospinal fluid (CSF) and blood samples that were taken from patients with meningitis. Our goal was to identify a fast and a reliable biomarker using these parameters in order to the early diagnose of bacterial meningitis.

Material and methods. In this study, 37 bacterial meningitis, 30 tuberculous meningitis and 30 viral meningitis cases were included. Serum/CSF total oxidant status (TOS) and total antioxidant status (TAS) were measured by the Erel method. Nitrotyrosine concentrations were quantified by using ELISA in both serum and CSF.

Results. Serum nitrotyrosine, CSF TAS and TOS levels were not significantly different in three groups (p>0.05). CSF nitrotyrosine levels were significantly higher in bacterial meningitis than tuberculous meningitis group (p<0.05). Viral meningitis patients had higher serum TOS and TAS concentrations than tuberculous meningitis group (p<0.05).

Conclusion. As a result, we can say that the oxidative and nitrosative stress markers studied are not a rapid and reliable biomarker in bacterial meningitis’s diagnosis.

 

Cite

Namiduru ES, Namiduru M, Karaoğlan İ, Koçak K. Oxidative and nitrosative stress in patients with meningitis. Eur J Clin Exp Med. 2022;20(1):70–74. doi: 10.15584/ejcem.2022.1.10

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited