Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development

Anna Sęk-Mastej
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Sabina Galiniak
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Izabela Krawczyk-Marć
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Krzysztof Balawender
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Artur Szymczak
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Maciej Kaniewski
Natalia Leksa
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Marek Biesiadecki
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Stanisław Orkisz
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Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland
Department of Biochemistry and General Chemistry Medical College of Rzeszów University, Rzeszów, Poland
Faculty of Medicine, University of Rzeszów, Rzeszów, Poland
Department of Morphological Sciences, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland
Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland
Department of Human Anatomy, Chair of the Morphological Sciences, Faculty of Medicine, University of Rzeszów, Rzeszów, Poland
Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland
Faculty of Medicine, University of Rzeszów, Rzeszów, Poland
Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland
Received: 14 April 2018 / Accepted: 3 June 2018 / Published: 30 June 2018

Abstract

Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology.

Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model.

Material and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects.

Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.

 

Cite

Sęk-Mastej A, Galiniak S, Krawczyk-Marć, I et al. Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development. Eur J Clin Exp Med. 2018;16(2):85–91. doi: 10.15584/ejcem.2018.2.1

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